Here, we show that fcepsilonri stimulation triggers the formation of microtubules in a manner independent of calcium Altogether, our data support a model where influx of ca 2+ is regulated by modulating actin cytoskeleton in part via dbn1, leading to mast cell activation and degranulation. Dynamic conversions between actin polymerization and depolymerization support mc degranulation.
Additionally, we found that displacement of the actin cytoskeleton and its continued association with fcεri impede the capacity of desensitized mcs to evoke the calcium response that is essential for mc degranulation. The ability to modulate the actin superstructure and calcium responses links dbn1 to the fcεri response leading to degranulation by mast cells A calcium signal is essential for degranulation, generation of eicosanoids and optimal production of cytokines in mast cells in response to antigen and other stimulants
Mast cells have been shown to have the capacity to reform granules following degranulation in vitro Demonstrate that regranulation also occurs in vivo
